A report from GHTC and Policy Cures Research examines how US federal funding for global health R&D is delivering impact both abroad and at home.

Search the GHTC website

Follow us in Kenya!

Read time:
PATH/Wendy Stone

This is an exciting week for the GHTC. Not only are we launching our “Breakthroughs” blog, but we’re also taking off on an amazing trip to Kenya to discover how global health research is changing people’s lives on the ground.

October 9, 2011 by Kaitlin Christenson

Mother and Child in Kenya

This is an exciting week for the GHTC. Not only are we launching our “Breakthroughs” blog, but we’re also taking off on an amazing trip to Kenya to discover how global health research is changing people’s lives on the ground. We can’t wait to share live updates on our blog from the trip, and give you a sense for the incredible progress taking place in Kenya. We’re very fortunate to be meeting with several GHTC members conducting ground-breaking work in Kenya. In Nairobi, we have plans to meet with local researchers from the Drugs for Neglected Diseases initiative (DNDi), the International AIDS Vaccine Initiative (IAVI), and the International Partnership for Microbicides (IPM). DNDi is leading an incredible effort to create new treatments for visceral leishmaniasis, or VL, a painful and deadly disease that affects half a million people worldwide each year. IPM and IAVI are leading work to develop new HIV prevention methods in the form a vaccine (IAVI), as well as gels, rings and other products women can use to protect themselves against HIV (IPM).

Also while we’re in Nairobi, the GHTC is meeting with several dedicated American officials working on global health research in Kenya. These committed US citizens work with agencies such as the State Department, the US Embassy, and the Centers for Disease Control and Prevention (CDC). They’ll share with us why the US Government thinks research for new global health tools is so critical to American interests at home and abroad.

After Nairobi, we’ll visit Kisumu in Western Kenya. Kisumu is home to some of the most exciting health research going on in Kenya, including an incredible partnership several US agencies have with the Kenya Medical Research Institute (KEMRI). The CDC has been working with KEMRI for 30 years, and we’ll be visiting some exciting research projects the CDC/KEMRI partnership is working on with GHTC members. For example, there’s some remarkable vaccine research going on in and around Kisumu—GHTC member Aeras is conducting research for a new tuberculosis (TB) vaccine among infants in the region. And we’ll get the chance to hear about a ground-breaking study, called HPTN 052, on using antiretroviral drugs for HIV prevention in couples. The Department of Defense (DoD) also has a long history of medical research in Kisumu that we’ll get the hear more about during our visit.

Finally, we’ll be visiting a great program in western Kenya run by our secretariat PATH. The program, called APHIA II, provides comprehensive health care and prevention services for diseases such as HIV and AIDS, TB, and links these services to others that improve maternal and child health. APHIA shows the impact of lifesaving tools - such as drugs, vaccines, bed nets, and other treatments – that only exist as a result of the research investments that helped to develop them.

We hope you’re as excited about the GHTC’s trip as we are. We’re thrilled to share these stories with you, and hope you follow us throughout the week.

About the author

Kaitlin ChristensonGHTC

Kaitlin Christenson is director of GHTC.

Other Breakthroughs Blog posts you may like:
PMI/Wellcome Trust
December 16, 2024

Research Roundup: Diagnostics funding, Mpox drug trial halted, New class of antivirals

Written by Hannah Sachs-Wetstone / GHTC
Read time:
Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email. Last week, Detect Diagnostics announced that it received approximately $5.9 million in grants from the Bill & Melinda Gates Foundation to support further development of the company’s infrared light-based point-of-care system and assays to detect protein biomarkers of infectious disease. The Visualization by Infrared PEptide Reaction (or VIPER) diagnostic technology can detect bacteria, viruses, and fungi directly from samples and is simple to use, fast, low-cost, sensitive, and portable, making it suitable for low- and middle-income countries, which face a high burden of infectious disease. The grants include specific funding to advance the development of a test to detect tuberculosis.Last week, the National Institute of Allergy and Infectious Diseases and Siga Technologies announced that patients are no longer being enrolled in a clinical trial testing the antiviral drug tecovirimat (or Tpoxx) as a treatment for mpox. The study’s Data Safety and Monitoring Board recommended cessation after the drug did not hasten lesion healing or pain relief in adults with mild to moderate clade 2 mpox at low risk for severe illness, and an additional assessment showed a less than 1 percent chance that the study would demonstrate efficacy if enrollment and follow-up were completed. This news comes amid the ongoing global outbreak of clade 1 mpox and following the 2022 global outbreak of clade 2 mpox. While this trial and another testing Tpoxx for mpox did not show that the drug helped to accelerate lesion healing, before 2022, no treatment candidate had been studied in people with mpox, and this research represents an important step in the ongoing work of finding tools to address mpox.A recently published study introduces a proof-of-concept for a novel class of antivirals targeting a type of enzyme essential to several families of viruses—which include several pathogens that scientists believe are most likely to cause the next pandemic—, potentially paving the way for a faster and more robust response to future outbreaks. The research team screened hundreds of thousands of compounds, using the ones they discovered to create an optimized drug candidate that was then tested in mice, finding that the candidate could treat COVID-19 on par with Paxlovid, remain effective even if the virus mutated, and cause minimal side effects. The researchers say they need an industry partner before they can test the compound in humans, but they are working on developing compounds that could target other priority viruses that share the targeted enzyme, including RNA viruses like Ebola and dengue, as well as cytosolic-replicating DNA viruses like mpox.
PMI
December 9, 2024

Research Roundup: New Hepatitis C vaccine design, WHO prequalifies first TB test, Malaria medicine recommended...

Written by Hannah Sachs-Wetstone / GHTC
Read time:
Interested in more global health innovation news? Every week GHTC scours media reports worldwide to deliver essential global health R&D news and content to your inbox. Sign up now to receive our weekly R&D News Roundup email. A research team was able to induce broadly neutralizing antibodies targeting hepatitis C virus (HCV) in laboratory models for the first time, providing a promising approach for a vaccine targeting the virus, which an estimated 58 million people globally are chronically infected with and which causes 290,000 deaths annually. HCV is identified as a globally prioritized pathogen for vaccine research and development by the World Health Organization, but developing a vaccine has been a challenge due to the high genetic diversity of the virus. This new approach, if proven successful in further studies, could not only bring us closer to an effective HCV vaccine that could help limit the spread of the virus but could also lay the foundation for a new generation of vaccines against other priority viruses.Last week, the World Health Organization (WHO) announced that it had granted prequalification to Cepheid’s Xpert MTB/RIF Ultra rapid diagnostic test for tuberculosis (TB), the first TB diagnostic test to be prequalified by WHO. The designation will hopefully help ensure broader access to the product, allowing for accurate and early detection of TB, especially drug-resistant TB. Within hours, the test detects the genetic material of Mycobacterium tuberculosis in sputum samples and identifies mutations associated with rifampicin resistance, a key indicator of multidrug-resistant TB. A recent report found that 8.2 million people—the highest number of cases recorded by WHO since it began global TB monitoring—were diagnosed with TB in 2023, underscoring the need for greater access to new and improved tools.Last week, the World Health Organization (WHO) announced that it had granted prequalification to tafenoquine, the first single-dose medicine for the prevention of Plasmodium vivax malaria, and also included tafenoquine, co-administered with chloroquine, in the new WHO malaria guidelines for South America. P. vivax is the dominant malaria parasite in most countries outside of sub-Saharan Africa, with children under five and migrant populations at particular risk. The prequalification and inclusion of tafenoquine in the updated guidelines are aimed at improving access to the treatment, which is shorter and simpler than current treatment regimens.