Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

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Ansley Kahn
Research Roundup: Ebola found in West African bat for the first time, global health R&D money reaches record high, and temperature-stable TB vaccine enters clinical testing

In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week.

Recent

Research Roundup: an Ebola vaccine, stillbirths, and antimicrobial R&D

Gavi, the Vaccine Alliance, signed an advanced purchase commitment, pledging to spend US$5 million on an Ebola vaccine currently under development by pharmaceutical company Merck & Co.

GHTC
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WHO’s Doing What?

With the New Year underway, GHTC is looking forward to a busy spring of multilateral organization meetings—with a number of them impacting global health research and development (R&D). First on the agenda is the World Health Organization (WHO) Executive Board (EB) meeting on January 25–30 in Geneva, where the EB will receive updates on a number of topics and make important decisions, particularly around how to proceed with the next steps of the Consultative Expert Working Group on Research and Development: Financing and Coordination (CEWG) process.

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Research Roundup: Vaccines for cholera and river blindness and an online platform for pooled procurement

Last week, an oral cholera vaccine received World Health Organization (WHO) prequalification, a process of regulatory review which paves the way for procurement by United Nations agencies and international organizations.

GHTC
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Harnessing health innovation to achieve the global goals

On January 1, the countdown to 2030 officially began with the implementation of the new global development goals.

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Welcoming the National Action Plan for Combating Multidrug-Resistant Tuberculosis: Important first steps, critical next steps

In this guest post, Dara Erck, vice president of external affairs at Aeras, discusses the new White House National Action Plan for Combating Multidrug-Resistant Tuberculosis and how it could accelerate research and development (R&D) of new technologies to combat multidrug-resistant TB (MDR-TB).

Aeras
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Obama highlights global health and innovation in State of the Union

GHTC has long championed US leadership in global health and innovation, and we were encouraged to see President Barack Obama highlight these themes in his State of the Union address.

GHTC
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Research Roundup: Ebola treatments, drug-resistant gonorrhea, and zoonotic tuberculosis

A recent clinical trial found that convalescent plasma therapy, a treatment in which the blood plasma is taken from survivors of a disease and used to treat current patients, did not prove to be effective against Ebola.

GHTC
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Research Roundup: MERS vaccine for camels, lessons learned from Ebola R&D, and more

A new vaccine against Middle East Respiratory Syndrome (MERS) could save human lives by boosting immunity in camels. MERS, a virus that causes an innocuous cold in camels but kills nearly one-third of human patients, is primarily found in the Arabian Peninsula, where camels are common and 12 percent are infected at any given time.

GHTC
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365 review: Top global health innovation news of 2015

As 2015 draws to a close, the Global Health Technologies Coalition is reflecting on the past year in global health innovation.

GHTC
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Research Roundup: flesh-eating bacteria treatment, Hepatitis C in Egypt, and access to compounds for drug discovery

Global Health Now took an in-depth look at the flesh-eating fungus mycetoma—which enters the body through cuts, and can result in swollen, deformed limbs—in a three-part series on this Untold Global Health Story of 2015.

GHTC
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PATH/Patrick McKern
Global Health Innovation Act has passed the House of Representatives

Last month, Representatives Albio Sires (D-NJ) and Mario Diaz-Balart (R-FL) introduced a new piece of legislation—the Global Health Innovation Act (H.R. 2241)—that would strengthen global health research and development (R&D) programming at the US Agency for International Development (USAID).

GHTC
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TB Alliance
Fruit-flavored drugs to saves kids’ lives: First correctly-dosed, child-friendly TB treatments developed

Early this month, GHTC member TB Alliance and its partners announced the creation of the first-ever appropriate, child-friendly tuberculosis (TB) medicine in the correct doses.

TB Alliance
TB Alliance
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A second chance for a TB research movement

In this guest post, Mike Frick, TB/HIV project officer at the Treatment Action Group (TAG), reflects on activist calls for greater investment in tuberculosis (TB) research and development (R&D) at the 46th Union World Conference on Lung Health and the stagnation of global TB R&D funding at a time of growing drug resistance.

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Research Roundup: Preterm birth indicators, African sleeping sickness treatment, and the world’s first dengue vaccine

Virginia Commonwealth University (VCU) received a grant from the Global Alliance to Prevent Prematurity and Stillbirth, a member of the GHTC, to study the human microbiome in search of biomarkers to predict preterm birth.

GHTC
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Transforming the lives of women and girls in sub-Saharan Africa and helping end AIDS through better HIV prevention research and development

In this guest post Tom Harmon, senior policy analyst at the International AIDS Vaccine Initiative (IAVI), and Anna Forbes, a globally recognized advocate for women’s HIV prevention needs, discuss a new piece proposing how HIV prevention research and development (R&D) for women and girls can better align with programs to improve their health and well-being.

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Research Roundup: the first kid-friendly TB treatment, enlisting smartphones to diagnose malaria, and promising new microbicides

GHTC member TB Alliance announced last week the creation of the first-ever child-friendly tuberculosis (TB) medicines, which are currently undergoing regulatory review by the World Health Organization and should be available in early 2016.

GHTC
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GHTC/Marissa Chmiola
Celebrating US leadership in global health R&D on Capitol Hill

On Wednesday evening, GHTC was joined on Capitol Hill by congressional champions—Congressman Adam Smith (WA-9) and Congresswoman Betty McCollum (MN-4)—and global health community members for a reception celebrating US leadership in global health research and development (R&D) and the launch of the 2015 G-FINDER report, which tracks investment in neglected disease R&D.

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Research Roundup: kid-friendly malaria medicine, Zika fever, priority review vouchers, and more

After four successful Phase 3 clinical trials enrolling more than 3,500 patients in 18 countries, the European Medicines Agency (EMA) has granted Pyramax® Granules, a pediatric malaria medicine, a positive opinion under Article 58—a mechanism through which the EMA reviews and issues a scientific opinion on products that are not intended for use in Europe.

GHTC
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What we’re thankful for in global health

It’s that time of year when Americans chow down on turkey with family and friends and express gratitude for the many things in life for which they are most thankful.

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Research Roundup: Snakebites, TB and parasitic infections, and HIV/AIDS vaccine development

Snakebites, which Médecins Sans Frontières describes as “one of the world's most neglected public health emergencies,” kill 200,000 people each year.

GHTC
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