Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

The Latest
Jamie Bay Nishi, MA
As America leads, other nations step up to fund R&D to combat neglected disease threats

The US government has long played an indispensable role in driving global health progress as the world’s leading funder of research and development (R&D) for new vaccines, treatments, and other tools to fight neglected diseases.

Recent

To meet the global goals, UN must include health R&D indicators in SDG framework

Later this month global leaders are poised to approve the Sustainable Development Goals (SDGs), but a new report commissioned by a leading group of health nonprofits including GHTC warns that the SDG targets will not be achieved without the development and introduction of new and improved health technologies to address the health needs of the world’s poorest people.

GHTC
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PATH/Eric Becker
Research Roundup: injectable HIV treatment, the role of health technologies in reaching SDGs, PrEP showing promise, and more

An injectable HIV/AIDS treatment that could offer HIV-positive individuals an option other than taking daily pills is entering late-stage clinical-trials.

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Pipeline report points toward nascent progress in the fight against tuberculosis

In this guest post, Lindsay McKenna, TB/HIV project officer at GHTC member Treatment Action Group (TAG), writes about a newly released report examining advancements in tuberculosis (TB) research and development (R&D).

Treatment Action Group
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PATH/Aaron Joel Santos
Research Roundup: priority review vouchers, diagnosing drug resistance, and oral and universal flu vaccines

Pharmaceutical company AbbVie is paying United Therapeutics US$350 million for its priority review voucher (PRV)—which expedites the US Food and Drug Administration’s (FDA) review of a product by four months—and EP Vantage speculates on their motive.

GHTC
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Research Roundup: a rapid diagnostic for three hemorrhagic fevers, a MERS vaccine to be tested in humans, and advances in R&D for HIV treatments

A new paper-based diagnostic can test for Ebola, dengue, and yellow fever in just ten minutes without running water, electricity, lab equipment, or highly-trained personnel.

GHTC
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Research Roundup: combatting malaria with forensics, detecting counterfeit drugs out of a suitcase, and preventing the flu without a vaccine

Luminol has long been used to detect blood at crime scenes, as it glows bright blue when it comes into contact with the blood protein hemoglobin, however, new research suggests that it could be repurposed to fight malaria in humans.

GHTC
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The latest in MERS R&D: Do we have the tools needed to prevent the next outbreak?

Since its discovery in 2012, cases of Middle East Respiratory Syndrome (MERS)—a disease World Health Organization (WHO) Director-General Dr. Margaret Chan called “a threat to the entire world”— have been reported in 27 countries across four continents.

GHTC
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Research Roundup: 3D-printed drugs, R&D in emergency settings, a universal flu vaccine, and more

The US Food and Drug Administration (FDA) approved the first 3D-printed drug last week, paving the way for the technology to be used to customize medical care to individual patients.

GHTC
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When breastfeeding is not possible: How an innovative cup can save lives

Breast milk is the perfect first food for newborns; it provides nutrients and energy that infants need and contains substances that strengthen their immune systems.

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Research Roundup: a Chagas vaccine, new pediatric clinical trial resources, the “Nursery of the Future,” and more

Sabin Vaccine Institute—a member of GHTC—and Texas Children’s Hospital Center for Vaccine Development received a US$1.8 million grant to expedite the research and development of the first therapeutic vaccine for Chagas disease, which is currently undergoing preclinical research by the same team.

GHTC
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New legislation aims to #SaveMomsandKids everywhere

In this guest post, Heather Ignatius—senior policy and advocacy officer at PATH—writes about a new bipartisan piece of legislation to accelerate progress towards ending preventable child and maternal deaths.

PATH
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New report on investment in R&D for HIV prevention highlights 2014 global funding trends

In this guest post, the HIV Vaccines & Microbicides Resource Tracking Working Group—comprised of AVAC as secretariat, the International AIDS Vaccine Initiative, and UNAIDS—discusses its new report examining investment in research and development (R&D) for HIV prevention options.

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Entering the Shark Tank for maternal and newborn health innovation

Last Wednesday 53 teams of innovators gathered at the International Trade Center in Washington, DC, for the Saving Lives at Birth DevelopmentXChange—an event resembling a cross between a science fair and an episode of Shark Tank.

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Research Roundup: a dengue vaccine, a breakthrough HIV treatment, antimicrobial R&D, and more

Later this year, French pharmaceutical company Sanofi plans to launch a vaccine for dengue fever, the first on the market for an infection for which nearly half of the world’s population is at risk.

GHTC
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Research Roundup: an aerosol vaccine for Ebola, software to enable clinical trials, an antibody against dengue fever, and more

An experimental, aerosol vaccine completely prevented infection from Ebola in monkeys, and will be tested in human clinical trials shortly.

GHTC
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PATH/Gabe Bienczycki
How to accelerate innovation to solve the world's most urgent health issues

In this post, Amie Batson, MBA—chief strategy officer at GHTC member PATH—discusses a new PATH-led initiative to identify and showcase lifesaving innovations with the promise to transform global health by 2030 and offers insights into what it will take to accelerate the impact of innovation. This post originally appeared in the Innovation Countdown 2030 Report: Reimagining Global Health.

PATH
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Research Roundup: bacteria-eating viruses, experimental HIV and flu vaccines, and pharmaceutical law

With the looming threat of a post-antibiotic era—in which minor infections are fatal due to growing drug resistance—world leaders are examining remedies for treating bacterial infections from the pre-antibiotic era.

GHTC
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Passing the ball: DNDi transfers malaria therapies to MMV

The Drugs for Neglected Disease initiative (DNDi) and the Medicines for Malaria Venture (MMV)—nonprofit product development partnerships (PDPs) and members of the Global Health Technologies Coalition—have teamed up to ensure two treatments for malaria continue to reach the patients who need them most.

GHTC
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Research Roundup: Drug-resistant TB, regulatory reform in India, a malaria vaccine, and more

A new study published in PLOS Medicine indicates that multi-drug resistant tuberculosis (TB) is less contagious than drug-susceptible TB.

GHTC
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Architect of the Capitol
Celebrating America’s contributions to global health innovation

This Independence Day, GHTC is taking a break from our cookouts and parades to celebrate America’s extraordinary contributions to advancing innovation to save lives around the world.

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