Breakthroughs Blog

Breakthroughs brings you stories of bright ideas and bold innovations in global health.

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Ansley Kahn
Research Roundup: Single-dose drug for recurrent malaria, long-acting contraceptive self-administered via microneedles, and fast diagnosis of viruses

In this regular feature on Breakthroughs, we highlight some of the most interesting reads in global health research from the past week.

Recent

PATH/Doune Porter
Four reasons to visit the Contraceptive Technology Innovation Exchange today

Over the past several decades, overall investment in contraceptive R&D has declined dramatically. The result? Renewed commitment and partnerships will be required to ensure that new contraceptive methods advance through the development pipeline and that access to the final products is affordable and equitable.

FHI360
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Research Roundup: a new contraceptive option, China’s role in global health R&D, and vaccines for MERS and pneumonia

Last week, GHTC member PATH launched the Caya® contoured diaphragm in the United States, after developing and testing nearly 200 prototypes to ensure the product was safe, effective, and user friendly.

GHTC
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PATH/Christopher Nelson
Research Roundup: a promising antimalarial and leishmaniasis vaccine, diagnostics for tuberculosis, and more

The Medicines for Malaria Venture (MMV)—a member of the GHTC—and the University of Dundee’s Drug Discovery Unit have developed an antimalarial compound that could treat drug-resistant cases of malaria with a single dose.

GHTC
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PATH/Nguyen Ba Quang
Research Roundup: Middle East Respiratory Syndrome R&D, G7 support for antimicrobial and neglected tropical disease R&D, patient safety and the 21st Century Cures Act, and the contraceptive pipeline

The zoonotic Middle East Respiratory Syndrome (MERS), which World Health Organization (WHO) Director-General Dr. Margaret Chan called “a threat to the entire world” has spread to South Korea. More than 100 cases and 10 deaths have been reported, making it the largest outbreak outside of the Arabian Peninsula.

GHTC
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Research Roundup: cross-sector partnerships to advance drug discovery, global recommendations for contraceptive use, and a diagnostic that detects lifetime viral exposure

The Drugs for Neglected Diseases initiative (DNDi)—a member of the GHTC—is partnering with pharmaceutical companies Eisai Co., Shionogi & Co., Takeda Pharmaceutical, and AstraZeneca to accelerate early-stage research for drugs against Chagas and leishmaniasis.

GHTC
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World Health Assembly roundup: News on global health research and innovation

The 68th World Health Assembly (WHA) in Geneva wrapped up last week after addressing several items that will shape the next few years of global health innovation.

GHTC
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New legislation would strengthen USAID’s role in global health R&D

Update: The Global Health Technologies Coalition is excited to announce that the Global Health Innovation Act (H.R. 2241) passed the House of Representatives on December 18.

GHTC
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Research Roundup: priority review voucher sells for record price, WHO action to address antimicrobial resistance, and more

The French pharmaceutical company Sanofi purchased a priority review voucher (PRV)—which entitles the owner to an expedited review of a future product by the US Food and Drug Administration (FDA)—for US$245 million last week.

GHTC
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21st Century Cures Act: What the global health community needs to know

Last week, the House Energy and Commerce Committee unanimously voted to approve the 21st Century Cures Act—a bill that aims to speed the development, approval, and introduction of new health technologies.

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CDC/Melissa Dankel
Research Roundup: US and European efforts to address growing antimicrobial resistance and legislation to advance medical breakthroughs

Members of the European Parliament are calling on the European Commission to adopt a resolution to combat the growing threat of antimicrobial resistance—which kills 25,000 Europeans annually.

GHTC
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PATH/Evelyn Hockstein
Four reasons now is the time to ramp up investment in HIV/AIDS vaccine R&D

This Monday, May 18 was HIV Vaccine Awareness Day (HVAD), and GHTC members AVAC, the International AIDS Vaccine Initiative (IAVI), and the Bill & Melinda Gates Foundation convened leaders in the field to discuss the state of HIV/AIDS vaccine research and development (R&D).

GHTC
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PATH/Christopher Nelson
Research Roundup: Big Pharma’s role in antibiotic R&D, clinical trials for Ebola vaccines and drug-resistant tuberculosis treatments, and more

How can we get Big Pharma to invest in low-cost antibiotic research and development (R&D)?

GHTC
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Will Boase
Research Roundup: inclusion of women in clinical trials, the future of vaccines, and diagnostics for counterfeit medicines and parasitic worms

United States Representatives Jim Cooper (D-TN) and Cynthia Loomis (R-WO) introduced the Research for All Act last week which calls for the inclusion of more women in clinical trials for products submitted for US Food and Drug Administration (FDA) approval.

GHTC
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Mothers of innovation: Five mothers who have transformed global health

Breakthrough ideas are like children—they start small, they need constant nurturing, they don’t always develop according to schedule, but they change lives forever.

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Seven takeaways on the post-2015 negotiations

Trying to navigate and understand the post-2015 negotiations can be a challenge, so to help add some clarity, last week the Global Health Technologies Coalition (GHTC) convened a panel of experts to help explain the ongoing debates and where the negotiations stand and how health innovation is reflected in the agenda.

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PATH/Lesley Reed
Research Roundup: leadership at USAID, investments in global health research at US universities, and measuring the impact of open innovation

United States President Barack Obama announced last week his intent to nominate Gayle Smith, senior director for Development and Democracy at the National Security Council, to lead the US Agency for International Development (USAID).

GHTC
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PATH/Evelyn Hockstein
Research Roundup: resistance to antimalarials in Africa, R&D for bioterrorist attacks, and more

Scientists at the London School of Hygiene and Tropical Medicine have identified a mutation in Plasmodium falciparum—the parasite responsible for the majority of fatal cases of malaria—that makes the parasite more resistant to quinine and artemisinin, the leading antimalarials worldwide.

GHTC
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Photo courtesy of the David and Lucile Packard Foundation.
Could climate change lead to chikungunya? Examining the link between climate change and health

Polar bears and penguins aren’t the only species threatened by climate change.

GHTC
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PATH/Patrick McKern
Research Roundup: publication of clinical trial results, the establishment of an African CDC, and more

The World Health Organization (WHO) released a statement last week calling for the publication of all data from clinical trials for drugs, vaccines, and medical devices.

GHTC
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PATH/Jennifer Fox
Research Roundup: research capacity building in Africa, lessons learned from the Ebola outbreak, and top health officials in the United States tell Congress to “think globally”

A new initiative seeks to develop research capacity within Africa and create a regional hub with the ability to determine research needs and award grants.

GHTC
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